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dc.contributor.authorKobyliak, N.-
dc.contributor.authorFalalyeyeva, T.-
dc.contributor.authorBoyko, N.-
dc.contributor.authorTsyryuk, O.-
dc.contributor.authorBeregova, T.-
dc.contributor.authorOstapchenko, L.-
dc.date.accessioned2019-11-30T21:00:01Z-
dc.date.available2019-11-30T21:00:01Z-
dc.date.issued2018-07-
dc.identifier.other10.1016/j.diabres.2018.05.005-
dc.identifier.urihttp://ir.librarynmu.com/handle/123456789/235-
dc.description.abstractThe beneficial interaction between the microbiota and humans is how bacteria contained within the gut 'talk' to the immune system and in this landscape, probiotics and nutraceuticals play a major role. The study aims to determine whether probiotics plus nutraceuticals such as smectite or omega-3 are superior to probiotic alone on the monosodium glutamate (MSG) induced obesity model in rats. METHODS: Totally, 75 rats divided into five groups were included (n = 15, in each). Rats in group I were intact. Newborn rats in groups II-V were injected with MSG. Group III (Symbiter) received 2.5 ml/kg of multiprobiotic "Symbiter" containing concentrated biomass of 14 probiotic bacteria genera. Groups IV (Symbiter-Omega) and V (Symbiter-Smectite) received a combination of probiotic biomass supplemented with flax and wheat germ oil (250 mg of each, concentration of omega-3 fatty acids 1-5%) or smectite gel (250 mg), respectively. RESULTS: In all interventional groups, significant reductions of total body and visceral adipose tissue weight as compared to MSG-obesity were observed. However, the lowest prevalence of obesity was noted for Symbiter-Omega (20% vs 33.3% as compared to other interventional groups). Moreover, supplementation of probiotics with omega-3 lead to a more pronounced decrease in HOMA-IR (2.31 ± 0.13 vs 4.02 ± 0.33, p < 0.001) and elevation of adiponectin levels (5.67 ± 0.39 vs 2.61 ± 0.27, P < 0.001), compared to the obesity group. CONCLUSION: Probiotics and nutraceuticals led to a significantly lower prevalence of obesity, reduction of insulin resistance, total and VAT weight. Our study demonstrated that supplementation of probiotics with omega-3 may have the most beneficial antiobesity properties.uk_UA
dc.language.isoenuk_UA
dc.publisherElsevieruk_UA
dc.titleProbiotics and nutraceuticals as a new frontier in obesity prevention and managementuk_UA
dc.typeArticleuk_UA
Розташовується у зібраннях:Наукові публікації кафедри ендокринології

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