Нelicobacter pylori як етіологічний чинник гострого панкреатиту та маркер розвитку його гнійно-септичних ускладнень

Abstract

Objective. Study of the role of Helicobacter pylori (HP) as an etiological factor of acute pancreatitis and a marker of the development of its purulent-septic complications. Маterials and methods. All 124 patients with acute pancreatitis at hospitalization underwent HP screening in faeces and serological blood tests. In 39 (31.5%) patients, bacteriological examination of biological material on HP was performed. Patients were divided into the main group (66 patients with severe acute pancreatitis and moderate) and the comparison group (58 patients with mild). Results. Positive results of fecal rapid test were obtained in 105 patients (84.7%). At serological examination of patients after 24 h from the moment of hospitalization in the comparison group a positive result was obtained in 8 (13.8%) patients, in the main - in 23 patients (34.8%); after 7 days - in 9 (15.5%) patients and in 42 (63.3%) patients, respectively. Antibiotics used for the treatment of purulent-septic complications of acute pancreatitis provide the effectiveness of HP eradication in 94.9% of cases. Conclusion. An increase in the number of positive results of serological examination by 28.5% (P <0.001) in patients of the main group after 7 days of hospitalization proves that HР is not only one of the etiological factors of acute pancreatitis, but also a possible marker of its purulent-septic complications.