Morphogenesis Of Chorionic Villi In Pregnant Women With Coronavirus Disease (Covid‑19)

Abstract

Villous chorion formation proceeds throughout gestation, encompassing stem, intermediate, and terminal villi. Exposure to adverse factors during pregnancy induces structural chorionic alterations that persist until delivery. SARS-CoV‑2, the causative agent of coronavirus disease (COVID‑19), directly activates endothelial cells, inducing microcirculatory disturbances alongside proliferative and inflammatory changes. Placental barrier integrity, nevertheless, permits delivery of neonates without detectable SARS-CoV‑2 RNA by PCR and devoid of clinical signs of infection.