The Role Of Early-Life Microbiota Programming And Age-Related Neuroendocrine Homeostasis Remodeling In The Modulation Of Cognitive Aging

Abstract

The role of early life microbiome programming and age related neuroendocrine homeostasis remodeling in the development of cognitive aging is considered. Current data on the influence of the gut brain axis, intestinal microbiota, neuroinflammation, insulin resistance, and hormonal changes on neuroplasticity, the functional state of the central nervous system, and the development of neurodegenerative processes are summarized. It is shown that early dysbiosis, impairment of the intestinal barrier function, chronic low grade systemic inflammation, and age related deficiency of neuroprotective hormones may represent important factors contributing to cognitive decline and the acceleration of neurodegenerative changes during aging.