Role Of Ketone Bodies In Neurotransmitter (Gaba, Glutamate) Metabolism During Excess Neuronal Activity

Abstract

Ketone bodies – β-hydroxybutyrate (BHB), acetoacetate (AcAc), and acetone – are not only alternative energy sources but also play a modulatory role in the regulation of neurotransmitter fluxes. Ketone metabolites are synthesized in the liver from fatty acids in response to reduced glucose availability, such as during fasting or adherence to a ketogenic diet. Under these conditions, they serve as alternative energy substrates for the peripheral tissues.