Comparison of the effects of niacin and a germanium–niacin complex on the fatty acid content of the brain, heart, liver and kidneys in female rats with acute ethanol intoxication

Abstract

According to WHO data, the morbidity and mortality associated with alcohol use disorders remain high despite a decline in overall consumption levels. Ethanol intoxication, both acute and chronic, has a profound impact on cellular components, the functional alterations of which may lead to cell necrosis not only in the liver but also in other organs such as the brain, heart and kidneys. Niacin is an essential human nutrient and has the ability to influence lipid metabolism. There is evidence that the complexation of organic molecules with metals may enhance their activity and provide new pharmacological effects. In particular, coordination compounds of germanium with niacin have demonstrated protective properties under conditions of toxic damage of various origins.