Recognizing melanoma in situ through dermoscopy: correlation with histopathology

Abstract

Melanoma in situ (MIS) represents the earliest stage of melanoma, strictly confined to the epidermis. At this stage, it may closely resemble benign melanocytic lesions such as Clark’s nevus, lentiginous junctional nevus, or solar lentigo. Because clinical appearance is often subtle, dermoscopy is essential for improving diagnostic accuracy by revealing early malignant clues, including asymmetry, gray dots or areas, and an atypical pigment network.