Peculiarities of microscopic and histochemical changes in the structure of the liver of experimental rats under the influence of viper venom Vipera berus nikolskii

Abstract

As a result of the significant distribution of poisonous animals, humanity is in constant contact with them, which often causes poisoning or fatal consequences. About 1.8-2.7 million cases of snake bites are registered every year, resulting in 81,000-138,000 deaths of the victims, and 100,000 of them are characterised by the development of irreversible physical or mental disorders. Their toxic substances show a wide range of pathological effects on most vital systems, causing damage to the lungs, heart, kidneys, and skeletal muscles. However, currently, the number of experimental works on the effect of the venom of various types of snakes and vipers on the morpho-functional changes of the liver is too limited. The study aims to study microscopic and histochemical changes in the liver of rats under the influence of viper venom Vipera berus nikolskii. Experimental studies were carried out on white, non-linear male rats. The animals were conditionally divided into control and experimental groups, ten individuals in each. Experimental rats were injected intraperitoneally with a semi-lethal dose (LD50) (1.576 mg·g-1) of Vipera berus nikolskii venom in a physiological solution