Formation of modern quality requirements roe dietary supplements containing silymarin

Abstract

Silymarin is a complex of flavonolignans obtained from Silybum marianum and widely used in dietary supplements intended to support liver function due to its antioxidant and hepatoprotective properties. The Ukrainian market of silymarin-containing dietary supplements has expanded significantly in recent years; however, considerable variability in active substance content and the absence of unified quality standards remain major concerns. Dietary supplements in Ukraine are regulated as food products, which limits mandatory requirements for standardization and analytical control compared to medicinal products. The aim of this study was to substantiate modern quality requirements for dietary supplements containing silymarin, based on its chemical characteristics, international pharmacopoeial approaches, and current national regulatory conditions.