Effect of melatonin on fibrinous and proteolytic activity of tissues of internal organs and blood plasma of wheat rats

Abstract

Questions of fibrinolysis attract the attention of a wide range of medical specialists in the clinical and theoretical areas. Depression of fibrinolytic activity is one of the pathogenetic factors in the development of thrombosis. Statistics on the occurrence of myocardial infarctions clearly demonstrate the daily dependence of this pathology, which may be due to circadian oscillations of the fibrinolytic potential. However, the effect of melatonin on the fibrinolytic activity of tissues is not sufficiently studied. In conducted experimental studies on non-linear males of white rats, it was found that melatonin causes an increase in the intensity of enzymatic and non-enzymatic fibrinolysis in plasma of blood and tissue of the heart. At the same time, in the lungs, liver, spleen and kidneys there is a decrease in total fibrinolytic activity due to inhibition of the enzymatic fibrin lysis and increased intensity of proteolytic destruction of low and high molecular proteins and collagen.