Результати застосування хімічної деструкції в комплексному лікуванні вогнищевої патології печінки

Abstract

Objective. To estimate the immediate results of application of chemical destruction with 10% solution of calcium chloride in complex of treatment in the patients, suffering focal hepatic pathology. Маterials and methods. In 2012 – 2019 yrs, using chemical destruction, the impact was delivered towards 104 tumoral foci (range from 1 tо 4) in the patients, suffering hepatocellular carcinoma (23.7%), colorectal cancer metastases (55.3%) and in noncolorectal cancer (21.1%). The foci diameter have constituted at average (2.60 ± 1.24) сm (in 1.0 – 4.0 сm range). Chemical ablation was performed, using injections of 10% solution of calcium chloride. Side –effects and answer of tumoral foci were estimated. Results. The specific postoperative complications rate (formation of abscesses in zone of destruction, development of hematomas and biliomas) have constituted 10.5%. There were observed a complete answer in the foci 1.0 – 1.5 сm in diameter, while the disease progress – concerning the foci 3,8 – 4,2 сm in diameter. Local recurrence have occurred in 15.8% patients. The answer degree trustworthily depended upon the tumoral foci density (r=0.529, р < 0.001). Including, complete answering was observed in 76.9% hypodense, 23.1% іsodense foci, and partial – concerning 37.8% hypodense, 29.7% іsodense and 32.4% of the foci of mixed structure. Stabilization of the disease was diagnosed, concerning 15.0% іso – and hypodense, 40.0% hyperdense and 45.0% with the foci of mixed structure, while a progress – concerning 85.7% hyperdense and 14.3%of the foci of mixed density. Conclusion. Іntratumoral injection of 10% solution of calcium chloride in the treatment of focal hepatic pathology is not accompanied by severe specific complications and mortality, the patients are survive the procedure satisfactory, which may be applied as a local tumoral control of tumoral foci up to 3.0 сm in diameter.