Pathomorphological changes of the placenta in coronavirus disease (COVID-19) in pregnant women at 19-32 weeks of gestation

Abstract

The morphology of the placenta (chorion) changes during pregnancy. Immature intermediate villi formed during the first two trimesters are developmental steps towards the stem villi. A cotyledon is the branching of a single stem villus into mature intermediate villi and terminal villi. Villous maturation disorders led to placental dysfunction, fetal growth retardation and intrauterine asphyxia. The formation of placental insufficiency in the case of coronavirus disease (COVID-19) in the mother in the second trimester of pregnancy prompted us to conduct this study. The choice of gestation periods in our study was related to the structural changes of the villous chorion that occur at the end of the second and the beginning of the third trimester of pregnancy. Purpose: to determine pathomorphological changes in the placenta of women who contracted COVID-19 at 19-32 weeks of gestation.