Роль протеїнкіназ RIPK1 та RIPK3 у механізмі некроптозу

Abstract

Necroptosis, a caspase-independent programmed necrosis, plays a role in the development of inflammatory, neurodegenerative, and oncological diseases. The key mediators of necroptosis are the protein kinases RIPK1 and RIPK3, which form a signaling platform for its activation. Their interaction triggers the phosphorylation of the effector pseudokinase MLKL, leading to disruption of the cell membrane integrity and cell death. Studying the mechanisms of necroptosis involving RIPK1 and RIPK3 opens new avenues for therapeutic targeting of this process.