Роль mutр53 в онкогенезі

Abstract

The work is devoted to studying the molecular mechanisms of tumors caused by mutations of the TP53 gene. Normally, the p53 protein regulates the cell cycle, apoptosis, DNA repair, and genomic stability. Mutations (mutp53) lead to the loss of the protective function of the protein, sometimes to the acquisition of new properties that contribute to malignant transformation, proliferation and invasiveness of cells. Special attention is paid the role of mutp53 in the formation of the aggressive phenotype of tumor cells and prospects its use as a therapeutic target.