Effects of nicotinic acid on protein oxidative modifications in experimental chronic heart failure

Abstract

A model of chronic heart failure experimental model was induced to rats based on the toxic effects of doxorubicin. The nature of changes in the content of protein peroxidation products (neutral and basic 2,4-dinitrophenylhydrazones) was established in cardiomyocytes and hepatocytes of rats which received weekly intramuscular doxorubicin for 5 weeks in a dose of 5 mg/kg body weight (bw) together with the daily intraperitoneal administration of nicotinic acid, 10 mg/kg bw. The obtained results pointed out reduced protein peroxidation in cardiomyocytes caused by nicotinic acid, in a chronic heart failure model in rats. This allows to consider nicotinic acid as a drug with a potential cardioprotective activity.