Platelets amino acids profile and cardiometabolic risk factors in patients with coronary artery disease and atrial fibrillation

Abstract

To found out connections between platelets amino acids profile and cardiometabolic risk factors in coronary artery disease patients with atrial fibrillation. 300 patients were divided into 3 groups: first (I) – 149 patients with coronary artery disease and without arrhythmias, second (II) – 123 patients with coronary artery disease and atrial fibrillation paroxysm and 28 patients in control group. In II group in comparison with I group were checked (P<0.05): increasing isoleucine (10.73 %), leucine (12.63 %) and decreasing threonine (23.05 %), serine (5.06 %), glycine (32.21 %), valine (30.83 %) levels in platelets amino acids profile; elevation of apolipoprotein B (29.91 %), C-reactive protein (40.93 %), interleucine-6 (22.93 %), trimethylamine (16.13 %) and trimethylamine-N-oxide (57.54 %) levels and fall of trimethylamine / trimethylamine-N-oxide ratio (26.16 %). Majority of correlations were found between glycine (total number = 12), threonine (total number = 6), glutamate (total number = 6), valine (total number = 6) and cardiometabolic risk factors. Platelets glycine correlated with age (r=-0.305), body mass index (r=-0.351), total cholesterol (r=-0.304), low density lipoprotein (r=-0.348), apolipoprotein A1 (r=0.373), apolipoprotein B (r=-0.347), interleucine-6 (r=-0.315), trimethylamine-N-oxide (r=-0.654), trimethylamine / trimethylamine-N-oxide ratio (r=0.688), prothrombin index (r=0.317), activated partial thromboplastin time (r=-0.365) and fibrinogen (r=-0.396), P<0.05.