Histological changes in the colon wall in adult patients with chronic slow-transit constipation

Abstract

A pathomorphological comparative case-control study was performed. The main group included 105 patients who underwent colectomy as a treatment for chronic slow-transit constipation in the period 2011 — 2023. The surgical intervention was indicated for patients with chronic slow-transit constipation, resistance to conservative treatment, and a notable decline in quality of life. The comparison group included 27 deceased persons who did not experience constipation during their lifetime. The patient exclusion criteria were Hirschsprung’s disease, proctogenic constipation (dysfunction of the rectum and pelvic floor), medication-associated constipation, as well as mental disorders. The histological and immunological examinations of samples were carried out in both groups, in the comparison group — appendix, ileum, cecum, colon and sigmoid colon.