Features of the condition of the perilimbal tissues of the eye during the surgical treatment of patients with open-angle glaucoma

Abstract

Primary open-angle glaucoma is a multifactorial chronic neurodegenerative disease characterized by acquired loss of retinal ganglion cells and subsequent optic nerve atrophy, and is often associated with increased intraocular pressure (IOP). As the leading cause of blindness and vision loss, glaucoma affects more than 70 million people worldwide (Tang et al., 2021), and unfortunately, there is no downward trend. Most currently available glaucoma treatments tend to target the formation of the aqueous humor or the uveal-scleral outflow pathway. They do not affect the primary outflow pathway, which is usually responsible for 70–90% of aqueous humor drainage into the circulatory system. However, dysfunction and blockage of this major pathway can lead to increased outflow resistance, increased IOP, and ultimately the development of glaucoma. Purpose: to investigate the condition of the perilimbal tissues of the eye during the surgical treatment of patients with open-angle glaucoma.