Prematurity and growth retardation: different causes of fetal coagulation disorders

Abstract

Abstract: prematurity and fetal growth retardation complicates in general one in five pregnancies. The combination of prematurity with severe growth retardation and hypoxia worsens the prognosis due to increase of periventricular hemorrhage incidence, and later coronary heart disease, hypertension, stroke, miscarriage and fetal growth retardation in own pregnancies in adulthood. The causes of impaired blood coagulation and fibrinolysis in retardated and premature newborns remain poorly understood. The goal of the study – to compare the parameters of blood acid-base and gases balance, coagulation and fibrinolysis in prematurity and growth retardation. Material and methods. Newborns of three clinical groups were examined. 24 full-term newborns with a postnatal diagnosis of I-II growth retardation stage constituted group I. 18 newborns of group II were born prematurely, corresponding to pregnancy term of 28-34 weeks.