Фармакологічне дослідження супозиторіїв для лікування доброякісних захворювань передміхурової залози

Abstract

ABSTRACT Rectal suppositories containing indole-3-carbinol (I3K) and meloxicam (Suppositories with Combined compoSition – PolyEthylene Oxide based, SCS-PEO) have been investigated on the model of turpentine prostatitis in male rats. Main efficacy criteria was androgenic saturation ("fern leaves"), the concentration of total and free testosterone in serum, fructose in seminal vesicles, the number of leukocytes in capillary blood and morphofunctional state of the prostate. The semi-quantitative assessment of the effect of SCS-PEO on the inflammation, local hemodynamic disorders, changes in the morphofunctional state of the acinus glands compared with the reference drugs. Introduction of SCS-PEO reduced leukocytosis (by 46.7%), the content of testosterone, although other indicators of androgenization of the body exceeded the data of animals without treatment. Histologically proved absence of inflammation in 67% of rats and its significant reduction in the rest. The most effective anti-inflammatory and prostoprotective agents were SCS-PEO (2.5 points) compared to meloxicam (4.5 points) and pumpkin seed oil (5 points) at 9 points in the group without treatment. The obtained results prove that SCS-PEO suppositories effectively inhibit the inflammatory process in the prostate, show a pronounced prostatic resistance, have no toxic effect and are suitable for prolonged use.