Peculiarities of the pharmaceutical analysis of the Clarithromycin substance by the method of high-performance liquid chromatography

Abstract

The actual task of this experimental study is to adapt the conditions of chromatography using the method of high-performance liquid chromatography (HPLC) for determining accompanying impurities of Clarithromycin substance taking into account the selection and properties of the stationary phase (chromatographic columns), the parameters of the mobile phase to obtain the separation of the peaks of accompanying impurities of Clarithromycin within the limits allowed by the State Pharmacopoeia of Ukraine (SPU), evaluation of the obtained results.