Standardization of platelet aggregation tests to evaluate condition of hemostasis

Abstract

The aim of the study was to develop the method of quantitative evaluation of the platelets state in patient based on their aggregation and implement it to the medical practice. The method is based on analysis of the following parameters: strength of the created clot, its disaggregation and calculation of the quantitative index, i.e. platelet functional activity index (PFAI). Than authors evaluated the aggregation features of platelets by PFAI in combination with their quantitative content in peripheral blood followed by identification of normal, hyperactive and hypoactive platelet unit of hemostasis. Eventually, the new algorithm for plasma rich growth factors application was developed and implemented based on features mentioned above. It can be used for treatment of patients at the departments for maxillofacial surgery and dentistry, providing good or satisfactory results in the absolute majority of patients. Evaluation of platelet unit of hemostasis functional state based on PFAI provides the opportunity to standardize the platelet aggregation method. The suggested method is based on the biological principle of maintaining the most important constants of homeostasis and can be recommended for the development of more effective therapeutic approaches in clinical practice using the regenerative potential of platelets.