http://ir.librarynmu.com/handle/123456789/1595 Thu, 23 Apr 2026 00:02:09 GMT 2026-04-23T00:02:09Z http://ir.librarynmu.com/handle/123456789/2337 Название: 42 Наукові читання імені О.О. Богомольця: матеріали науково-практичної конференції з міжнародною участю Sat, 01 May 2021 00:00:00 GMT http://ir.librarynmu.com/handle/123456789/2337 2021-05-01T00:00:00Z http://ir.librarynmu.com/handle/123456789/2014 Название: Синдроми травматичної хвороби при черепно-мозковій травмі Авторы: Зябліцев, С. В.; Єльський, В. М. Краткий осмотр (реферат): У монографії представлено подальший розвиток експериментального обґрунту-вання концепції індивідуальної реактивності в умовах травматичної хвороби при черепно-мозковій травмі. Виділено основні синдроми розвитку хвороби (нейроендокринної дизрегуляції, ендогенної інтоксикації, запального, імунодефіцитного і аутоімунного, функціональних розладів ЦНС), представлений їх патогенез, динаміка розвитку, стадійність, критерії та методи діагностики. Обґрунтовано напрямок патогенетичної терапії за допомогою нейропротектора карбацетама. Призначена для наукових співробітників, викладачів медичних ВНЗ, травматологів, реаніматологів, нейрохірургів та лікарів інших спеціальностей, а також студентів медичних вузів. У книзі 182 ілюстрації (47 таблиць і 134 малюнка), список використаних джерел літератури включає 267 найменування. The monograph presents the further development of the experimental substantiation of the concept of individual reactivity in conditions of traumatic disease in traumatic brain injury. The main syndromes of these disease development (neuroendocrine dysregulation, endogenous intoxication, inflammatory, immunodeficiency and autoimmune, CNS functional disorders) are highlighted, their pathogenesis, dynamic, stage, criteria and methods of diagnosis are presented. The direction of pathogenetic therapy with the help of a carbacetam neuroprotector is substantiated. It is intended for researchers, teachers of medical universities, traumatologists, resuscitators, neurosurgeons and doctors of other specialties, as well as students of medical universities. In the book is presenting 182 illustrations (47 tables and 134 figures), the list of sources used includes 267 titles. Wed, 01 Jan 2020 00:00:00 GMT http://ir.librarynmu.com/handle/123456789/2014 2020-01-01T00:00:00Z http://ir.librarynmu.com/handle/123456789/1783 Название: Systemic effects of unspecific inflammatory reaction at traumatic brain injury Авторы: Зябліцев, С. В. Краткий осмотр (реферат): To determine the role of systemic effects of inflammation at traumatic brain disease caused by severe trau- matic brain injury. The study is performed on 65 white outbred male rats. TBI is applied with one blow on animal’s cranial vaults with blow energy of 0.52 J. The rate of mortality within the first 5 days after the injury is 87%. Experimental animals have got severe closed TBI. Blood contents of circulating immune complexes, C-reactive protein, ceruloplasmin, proinflammatory - interleukins(IL-1b, IL-6, IL-8 and tumor necrosis factor a -TNF-a) are investigated. The circulating immune complexes levels are increased 3.1 times in 24 hours and 4.4 times on the 5th days of trauma reflecting the progressive accumulation of metabolites and toxins in brain tissue and in the blood of injured animals. Blood levels of C-reactive protein are mark- edly increased in all periods of observation exceeding the control levels 3.5 times in 3 hours and 21.3 times after 5th day of trauma. Thus the study results suggest that the acute phase of systemic inflammation sets at the end of the 1st day after the trauma and it progresses in the course of traumatic brain disease. Blood contents of IL-1b increases continuously: 4.7 times in 3 hours; 7.6 times in 24 hours; and 17.4 times on the 5th day after trauma. The other interleukins levels are also increased but to a lesser extent. The coherence of changes in levels of circulating immune complexes, acute-phase proteins and interleukins indicates a pathogenic pattern of the acute period of traumatic disease at traumatic brain injury: spreading of damage processes with the involvement of body organs and tissues and the establishment of a systemic inflammatory reaction stage from the second day of posttraumatic period. Fri, 01 Jan 2016 00:00:00 GMT http://ir.librarynmu.com/handle/123456789/1783 2016-01-01T00:00:00Z http://ir.librarynmu.com/handle/123456789/1778 Название: Influence of rs1137101 gene polymorphism of leptin receptor on the development of diabetes mellitus type 2 and obesity Авторы: Зябліцев, С. В. Краткий осмотр (реферат): The aim of this research was a study of gene LEPR polymorphism rs1137101 role in diabetes mellitus 2 type development and his influences on the clinical and laboratory data, related to obesity for these patients. 103 patients are inspected, that had the clinically expressed complications. A control group was made by 100 practically healthy persons of corresponding age. The analysis of polymorphic DNA-loci was carried out by the method of polymerase chain reaction in real time (TaqMan® SNP Genotyping Assay). Results showed that allelic polymorphism of rs1137101 (223Gln>Arg) had been associated with diabetes mellitus 2 types development: allele Gln promotes, while allele Arg – reduces (OR=1.5; P=0.039) the risk of its development. Presence allele Gln for diabetic patients assists development of obesity and his displays, namely – to the higher values of body mass index and HOMA-IR, and also to the greater leptin and tri- glycerides blood levels on a background reduction of high-density lipoproteides maintenance. The risk of developing obesity in these patients is increased by 1.8 times. Mon, 01 Jan 2018 00:00:00 GMT http://ir.librarynmu.com/handle/123456789/1778 2018-01-01T00:00:00Z