http://ir.librarynmu.com/handle/123456789/18629 2026-04-10T01:16:26Z http://ir.librarynmu.com/handle/123456789/18647 Название: General Surgery №4 (15) 2025 2025-01-01T00:00:00Z http://ir.librarynmu.com/handle/123456789/18646 Название: Prevention and treatment of acute secondary sarcopenia in patients with infected necrotizing pancreatitis. Literature review Авторы: Teterina, V. Краткий осмотр (реферат): This review of the current scientific literature focuses on the etiological factors, pathophysiological mechanisms, diagnostic approaches, and methods of prevention and treatment of acute secondary sarcopenia in patients with acute necrotizing pancreatitis. Acute secondary sarcopenia represents a severe complication of acute pancreatitis, resulting from a combination of systemic inflammation, physical inactivity, and nutritional deficiency. Scientific evidence indicates that sarcopenia and sarcopenic obesity are associated with higher mortality, an increased incidence of complications in acute pancreatitis, and longer hospital stays. According to the literature, the prevalence of secondary sarcopenia among patients with acute pancreatitis ranges from 18 % to 70 – 80 %, with variability in these indicators attributed to differences in diagnostic approaches, assessment criteria, and clinical characteristics of the patient cohorts studied. Contemporary studies have explored various approaches to diagnosing this condition, emphasizing the importance of early detection of secondary sarcopenia through functional tests, imaging, and instrumental diagnostic methods. It has been demonstrated that the prevention and treatment model for secondary sarcopenia requires a multidisciplinary team approach and includes effective anti-inflammatory therapy, optimization of nutritional support (early enteral nutrition with adequate protein and energy provision and correction of micronutrient deficiencies), the use of nutrients with anti-catabolic and anti-inflammatory properties (omega-3 polyunsaturated fatty acids, b-hydroxy-b-methylbutyrate, creatine), as well as early mobilization according to an individualized physiotherapy program. Clinical observations have confirmed that such interventions are associated with improved preservation and restoration of muscle mass and functional status, which directly influence survival rates, hospital stay duration, risk of complications, and disability. In summary, the review of international publications enabled the synthesis of current evidence on the diagnosis, prevention, and treatment of secondary sarcopenia in patients with acute necrotizing pancreatitis. The limited number of studies addressing this issue in the context of complicated acute pancreatitis underscores the relevance and necessity of further research aimed at refining and identifying optimal preventive and therapeutic strategies in this patient population. 2025-01-01T00:00:00Z http://ir.librarynmu.com/handle/123456789/18644 Название: Minimally invasive percutaneous interventions in the final stage of treatment of infected necrotizing pancreatitis. Review of recent studies Авторы: Dyrda, O. Краткий осмотр (реферат): Infected necrotizing pancreatitis represents one of the most challenging conditions in abdominal surgery and requires multi-stage minimally invasive interventions as part of the widely accepted step-up approach. This strategy involves collaboration between interventional radiologists and interventional gastroenterologists. Navigation-assisted minimally invasive interventions are crucial during the initial 3 – 4 weeks of the disease, serving as the primary method for managing infected necrotic collections in the retroperitoneal tissue. 2025-01-01T00:00:00Z http://ir.librarynmu.com/handle/123456789/18643 Название: Clinical characteristics of stem cell application in the surgical management of post-traumatic and trophic skin defects. Literature review Авторы: Avtomieienko, O. Краткий осмотр (реферат): Chronic post-traumatic and trophic skin defects present a significant clinical challenge, particularly in the context of ischemia, infection, diabetic angiopathy and neuropathy, or severe traumatic injuries. Conventional treatments such as debridement, skin grafts, and local or free flaps often fail to achieve durable healing, thereby increasing interest in regenerative technologies. Mesenchymal stem cells (MSCs), particularly those derived from bone marrow and adipose tissue (ADSCs), exert significant paracrine, angiogenic, and immunomodulatory effects. These properties enhance the wound microenvironment and augment the efficacy of standard surgical interventions. Clinical studies and meta-analyses indicate that autologous MSC therapy accelerates healing of diabetic, venous, arterial, and mixed ulcers, decreases the risk of amputation, and improves tissue perfusion. In reconstructive surgery for post-traumatic defects, ADSC/SVF-assisted lipofilling and nanofat technologies are widely utilized. These approaches promote scar tissue remodeling, improve tissue elasticity, reduce contractures, and optimize conditions for subsequent flap reconstruction. Furthermore, cellular or cell-matrix constructs (MSCs combined with scaffolds) have the potential to manage complex soft-tissue defects with bone exposure, thereby reducing the need for extensive reconstructive procedures. Despite these promising outcomes, current evidence is limited by small sample sizes, methodological heterogeneity, the absence of standardized dosing protocols, and a lack of large multicenter randomized controlled trials. Furthermore, although no significant risks have been reported in existing studies, the issue of long-term oncological safety warrants continued monitoring. Emerging strategies include cell-free approaches such as exosomes and MSC secretions. Additionally, the integration of cellular technologies with 3D-printed and bioengineered matrices, as well as the development of standardized surgical algorithms that leverage MSCs to enhance the efficacy of conventional reconstructive techniques, are being explored. 2025-01-01T00:00:00Z