http://ir.librarynmu.com/handle/123456789/18574 2026-04-08T14:10:53Z http://ir.librarynmu.com/handle/123456789/19267 Название: Quantitative Evaluation Of Cd34 Immunohistochemical Expression In The Placenta In Pregnant Women With Covid-19 Авторы: Savchuk, T.; Leshchenko, I. Краткий осмотр (реферат): Coronavirus (SARS-CoV-2) is the causative agent of the novel viral disease COVID-19. SARS-CoV-2 affects organs whose cells demonstrate a high level of expression of angiotensin-converting enzyme 2 (ACE2). The action of SARS-CoV-2 leads to necrotic and apoptotic changes in the syncytiotrophoblast and in the endothelium of chorionic villous vessels despite protective mechanisms against vertical transmission, including decreased activity (coexpression) and concentration of angiotensin-converting enzyme type II (ACE2) in the placenta. 2026-01-01T00:00:00Z http://ir.librarynmu.com/handle/123456789/16988 Название: Коронавірусна хвороба 2019 (COVID 19) при вагітності: патоморфологічні ультраструктурні зміни плаценти Авторы: Савчук, Т. В.; Лещенко, І. В.; Васлович, В. В.; Черненко, О. Г.; Малишева, Т. А. Краткий осмотр (реферат): Мета роботи – дослідити ультраструктурні зміни плаценти при COVID-19 у вагітної в другому та третьому триместрах гестації. 2025-01-01T00:00:00Z http://ir.librarynmu.com/handle/123456789/16753 Название: Rare embryonal tumor of the central nervous system in newborns: case report and comparative clinical analysis Авторы: Panina, A.; Kuzyk, P.; Savchuk, T.; Zhovnir, V.; Zhovnir, A. Краткий осмотр (реферат): A retrospective analysis was conducted of an autopsy case involving a deceased premature female neonate diagnosed with a CNS embryonal tumor, NOS. The material was obtained from the Division of Pathological Anatomy of the National Specialized Children’s Hospital “Ohmatdyt” of the Ministry of Health of Ukraine. The morphological diagnosis was established based on macroscopic and microscopic examination. 2025-01-01T00:00:00Z http://ir.librarynmu.com/handle/123456789/16428 Название: Coronavirus disease 2019 (Covid-19) during pregnancy Pathomorphological changes in the terminal villi of the placenta Авторы: Savchuk, T.; Leshchenko, I.; Vaslovych, V.; Chernenko, O.; Malysheva, T. Краткий осмотр (реферат): ABSTRACT Aim: To investigate the pathomorphological changes in the terminal chorionic villi during COVID-19 in pregnant women. Materials and Methods: A total of 123 placentas were studied in cases of live term births (groups І) and antenatal asphyxia (groups ІІ). The subgroups were defined as follows: II.2 and I.2 (post-COVID interval of 1–4 weeks); I.1 and II.1 (5–16 weeks). Morphological and statistical research methods were applied. Results: Spherical structures resembling viral particles were identified in the placenta. In 100 % of the observations, damage to the microcirculatory bed of terminal villi was detected, manifested by cytoplasmic edema of endothelial cells, disruption of cell membranes, nuclear apoptosis and placentitis. With increasing duration of the post-COVID interval, a gradual restoration of endothelial functional activity was observed, evidenced by an increase in laminar microvilli and vesicles, as well as widening of the vascular lumen; whereas in cases of antenatal asphyxia, obliteration of the vascular lumen and stromal fibrosis were noted. A reduction in endothelial cell cytoplasmic edema and stromal edema of terminal chorionic villi was also observed. Conclusions: The morphogenesis of placental dysfunction in cases of antenatal fetal asphyxia associated with immature protective mechanisms involves endothelial dysfunction, impaired microcirculation, inflammatory infiltration, stromal edema of terminal villi with a reduction in vascular lumen, and subsequent fibrosis. The detection of viral particles with increasing post-COVID interval suggests persistence of SARS-CoV-2, the long-term effects of which on vascular function and its role in the development of placental insufficiency require further investigation. 2025-01-01T00:00:00Z