http://ir.librarynmu.com/handle/123456789/122 2026-04-13T17:26:07Z http://ir.librarynmu.com/handle/123456789/995 Название: Non-cyclic epidemic process of invasive bacterial infections Авторы: Мохорт, Г. А. Краткий осмотр (реферат): The paper substantiates the hypothesis of non-cyclic (non-classical) the nature of the epidemic process of invasive bacterial infections with a predominantly sporadic morbidity and low natural susceptibility of the population, but if significant changes occur in the natural and social conditions, these infections may manifest outbreaks of diseases with high mortality. В статье обоснована гипотеза нециклического (неклассического) характера эпидемического процесса инвазивных бактериальных инфекций с преимущественно спорадической заболеваемостью и незначительной естественной восприимчивостью населения. Эти инфекции могут проявляться эпидемическими вспышками с высокой смертностью и летальностью при существенных изменениях природных и социальных условий. У статті обґрунтовується гіпотеза нециклічного (некласичного) характеру епідемічного процесу інвазивних бактеріальних інфекцій з переважно спорадичною захворюваністю та незначною природною сприйнятливістю населення. Ці інфекції можуть проявлятися в епідемічних спалахах з високою смертністю та летальністю при суттєвих змінах зовнішніх природних і соціальних умов. 2017-01-01T00:00:00Z http://ir.librarynmu.com/handle/123456789/246 Название: Effect of probiotic on serum cytokines and matrix metalloproteinases profiles during monoiodoacetate-induced osteoarthritis in rats Авторы: Korotkyi, O.; Vovk, A.; Galenova, T.; Vovk, T.; Dvorschenko, K.; Luzza, F.; Abenavoli, L.; Kobyliak, N.; Falalyeyeva, T.; Ostapchenko, L. Краткий осмотр (реферат): BACKGROUND: Cytokines (CKs) and matrix metalloproteinases (MMPs) play a major role in the pathogenesis of osteoarthritis (OA). The recent studies showed the effect of probiotics (PBs) on inflammatory processes during OA, but available results are limited and conflicted. In this study, we investigated the effect of alive probiotic on the levels of CKs (interleukins [ILs] IL-1β, IL-4, IL-10, IL-12 p40, tumor necrosis factor [TNF]-α, interferon [IFN]-γ) and MMPs (MMP-1, MMP-2, MMP-3, MMP-8) in rats with monoiodoacetate-induced OA. METHODS: We used a single injection of monoiodoacetate through the infrapatellar ligament of nonlinear male rats to start OA model (1st day of the experiment). Therapeutic groups got an intragastric feeding of PB composition (“Symbiter” O.D. Prolisok, Kyiv, Ukraine) from 8th to 21st. Sampling (serum, knee joint) was provided on the 30th day. The pathophysiological aspects of OA was described by histology assessment of knee cartilage. The levels of CKs and MMPs were measured in serum by enzyme-linked immunosorbent assay. RESULTS: OA model caused a significant increasing the levels of pro-inflammatory CKs (IL-1β, TNF-α, IFN-γ), and all studied MMPs, while IL-4 and IL-10 were decreased, comparing to group without OA (except IL12 p40, no significance changes in all groups). An application of the PB had positive effect on the levels of CKs and MMPs. CONCLUSIONS: The use of the PBs has anti-inflammatory effect during experimental OA. Thus, action of PB is promising and further investigations are waited with interest. 2019-05-01T00:00:00Z http://ir.librarynmu.com/handle/123456789/243 Название: The correction of the metabolic parameters of msg-induced obesity in rats by 2-[4-(benzyloxy) phenoxy] acetic acid Авторы: Konopelniuk, V.; Falalyeyeva, T.; Tsyryuk, O.; Savchenko, Y.; Prybytko, I.; Kobyliak, N.; Kovalchuk, O.; Boyko, A.; Arkhipov, V.; Moroz, Y.; Ostapchenko, L. Краткий осмотр (реферат): Epidemiological data showed that the number of obese people increases swiftly in all countries. Obesity can evoke metabolic syndrome or second type diabetes (T2D). So, the aim of our study was to investigate the influence of 2-[4-(benzyloxy) phenoxy] acetic acid on metabolic parameters of monosodium glutamate (MSG)-induced obesity in rats. We divided the rats as follows: 1- control group, 2 - MSG-group, 3 - MSG + 2-[4-(benzyloxy) phenoxy] acetic acid group. We investigated anthropometric parameters and blood biochemistry. It was established that MSG induced the development of visceral obesity in rats, in particular, it increased the Lee index, body mass index, deposits of subcutaneous, gonadal and visceral adipose tissue. The administration of 2-[4-(benzyloxy) phenoxy] acetic acid decreased metabolic parameters evoked by MSG. After obesity induction, there was recorded significant growth of cholesterol, triglycerides, and LDL cholesterol blood levels and significant decline in HDL cholesterol blood levels. There was a significant reduction in triglycerides, LDL cholesterol and VLDL, in 2-[4-(benzyloxy) phenoxy] acetic acid - treated group. Our results represent the basis for development of new treatment of obesity and associated conditions. 2018-01-01T00:00:00Z http://ir.librarynmu.com/handle/123456789/242 Название: Probiotics and smectite absorbent gel formulation reduce liver stiffness, transaminases and cytokine levels in NAFLD associated with type 2 diabetes: a randomized clinical study Авторы: Kobyliak, N.; Abenavoli, L.; Mykhalchyshyn, G.; Falalyeyeva, T.; Tsyryuk, O.; Kyriienko, D.; Kononenko, L.; Komisarenko, I. Краткий осмотр (реферат): Introduction: In double-blind single center randomized clinical trial (RCT), the efficacy of alive probiotics supplementation with smectite gel vs. placebo in type 2 diabetes patient with NAFLD detected on ultrasonography (US) were studied. Methods. A total of 50 patients met the criteria for inclusion. They were randomly assigned to receive Symbiter Forte combination of probiotic biomass with smectite gel (250 mg) or placebo for 8-weeks. The primary main outcomes were the change in fatty liver index (FLI) and liver stiffness (LS) measured by Shear Wave Elastography (SWE). Secondary outcomes were the changes in transaminases activity, serum lipids and cytokines levels. Results. All subjects completed the study and received more than 90% of prescribed sachets. In respect to our primary endpoints, FLI and LS insignificant decrease in both interventional and placebo groups. However, when we compare mean changes across groups from baseline, expressed in absolute values, the reduction of both LS (-0.254±0.85 vs. 0.262±0.77; p=0.031) were observed. Analysis of secondary outcomes showed that co-administration of probiotic with smectite lead to significant reduction of ALT, AST, total cholesterol, IL-1β, and TNF-α after 8 weeks. Conclusion. In this RCT, we confirmed previously reported animal data, showing that co-administration of probiotic with smectite manifested with reduction of LS, liver transaminases and chronic systemic inflammation. 2019-09-01T00:00:00Z