http://ir.librarynmu.com/handle/123456789/106 2026-06-15T03:25:35Z http://ir.librarynmu.com/handle/123456789/13753 Название: Topical Application of Autologous Plasma-Derived Plasminogen Accelerates Healing of Chronic Foot Ulcers in Type 2 Diabetes Patients Авторы: Petrenko, O.; Badziukh, S.; Korsa, V.; Kolosovych, I.; Tykhomyrov, A. Краткий осмотр (реферат): Plasminogen (Pg) is currently considered a master regulator of wound healing, but the molecular mechanisms of its efficacy in improving impaired closure of chronic skin ulcers in type 2 diabetes patients remain unclear. Here, we investigated wound healing effects of autologous plasma-derived Pg in diabetes patients with chronic foot ulcers and evaluated Pginduced changes in levels of key protein markers related to wound repair. Type 2 diabetes patients with chronic wounds of lower extremities were included in the study and received topical applications of Pg in a dose of 1.0 mg/mL every 2 days during 20 days, in addition to the standard wound management treatment. Patients treated only according to conventional protocol served as a control. Wound closure rates were monitored by digital planimetry of wound areas. Plasminogen supplementary treatment significantly accelerated relative wound closure as compared with diabetes patients from the control group (24 ± 4 days vs 120 ± 17 days, respectively, P < .01). As shown by Western blot, Pg application reduced expression of protein regulators of hypoxia events, angiogenesis, and autophagy such as hypoxia-inducible factor-1α (by 6.3-folds, P < .01), angiostatins (by 2.5-folds, P < .05), and autophagy marker LC3-II/LC3-I (by 8.6-folds, P < .05), while increasing vascular endothelial growth factor level by 1.9-folds (P < .05). Gelatin zymography showed that Pg-supplemented therapy decreased activity of matrix metalloproteinase-9 (MMP-9) by 3.5-folds at the end of treatment period (P < .01). We report here for the first time that topically applied plasma-derived Pg has a pronounced beneficial effect in promoting foot ulcer healing in patients with type 2 diabetes through preventing hypoxia-induced signaling, reducing autophagy flux, diminishing excessive MMP activity, and enhancing angiogenesis. 2026-01-01T00:00:00Z http://ir.librarynmu.com/handle/123456789/16436 Название: Удосконалення методів профілактики та лікування післяопераційного гіпоспленізму при травматичних ушкодженнях селезінки Авторы: Колосович, І. В.; Ганоль, І. В. Краткий осмотр (реферат): З розвитком вторгнення росії в Україну та широкомасштабного застосування нею вогнепальної зброї переважно вибухового характера, виникла велика кількість ран та поліструктурних дефектів тканин, ліквідація яких вимагає етапних складних оперативних втручань повторних хірургічних обробок з ВАК–терапією, закриття отриманих ранових дефектів шляхом дерматопластики, ангіосомними шкірно–м’язовими клаптями та ін. Реабілітація їх довоготривала, з розвитком часткової або повної втрати працездатності(боєздатності),а часто – інвалідизації. Тому пошук найдієвої терапії залишається досі актуальною проблемою. 2025-01-01T00:00:00Z http://ir.librarynmu.com/handle/123456789/16297 Название: Choice Of Tactics For Palliative Surgical Treatment Of Patients With Unresectable Pancreatic Head Cancer Complicated By Obstructive Jaundice In Cases Of High Surgical And Anesthetic Risk Авторы: Bezrodnyi, B.; Kolosovych, I.; Hanol, I.; Slobodianyk, V.; Cherepenko, I.; Chemodanov, P.; Nesteruk, Y. Краткий осмотр (реферат): The disadvantages of open operations to eliminate biliary obstruction and duodenal obstruction in patients with unresectable pancreatic head cancer are a high incidence of postoperative complications (up to 40%) and mortality (up to 15‒20%). When installing self-expanding metal stents (SEMS), the incidence of complications and mortality varies within 1‒3%. However, during surgical bypass operations, effective drainage of the biliary system and stomach lasts for more than a year, and SEMS are subject to obstruction with the development of cholangitis 6 months after installation. 2025-01-01T00:00:00Z http://ir.librarynmu.com/handle/123456789/16296 Название: A clinical case of surgical treatment of complicated chronic venous insufficiency using the principles of hemodynamic management Авторы: Kolosovych, I.; Korolova, K. Краткий осмотр (реферат): Chronic venous disease is a widespread condition that involves telangiectasias, reticular veins, varicose veins, and venous ulcers. In addition to the well-known manifestations and complications, long-term persistent chronic venous insufficiency (CVI) can become a factor that contributes to the development of infectious processes in the skin and subcutaneous fat. If the inflammatory lesion spreads deeper, phlegmon and deep vein thrombosis may occur. 20 % to 50 % of patients suffering from deep vein thrombosis develop post-thrombotic syndrome. 2025-01-01T00:00:00Z